The same is true for trigger points in the skeletal muscles

　　This additional irritating factor triggers an afferent sensory flow to the central nervous system, which is interpreted by the brain as pain. This mechanism is partially described by the generation Shoe Upper Knitting Machine of pain in the area of motor trigger points. We have to consider that the terminal parts of the sensory and motor neurons are located in the soft tissues, including skeletal muscles. In other words, it would be logical to assume that something must irritate the terminal parts of sensory and motor neurons. This something is a tension in the skeletal muscles, including trigger points that are not associated with motor trigger points (since they are located in other parts of the skeletal muscle).

Keep in mind that any inflammatory condition, whether in motor end plates or in muscular tissue, means that there is a decreased amount of blood supply to this inflamed tissue. From this it follows that gradual ischemic compression can be viewed as an anti-inflammatory effort.There is no doubt that myofascial pain can be the result of peripheral nerve abnormalities. An example of this would be the irritation of the sciatic nerve by an over-tensed piriformis muscle resulting in the formation of trigger points in muscles innervated by the sciatic nerve. This list can be continued because any peripheral nerve's entrapment in the key areas will cause formation of trigger points in muscles innervated by this nerve.If one examines a patient with peripheral arterial disorder (e.g., Buerger’s disease) one will find numerous active and dormant trigger points in the leg and foot muscles. It would most certainly be agreeable that insufficient arterial blood supply as a result vascular abnormality is responsible for the formation of trigger points in the skeletal muscles rather than abnormalities in the motor end-plates.

The same is true for trigger points in the skeletal muscles, which are developed as a result of chronic visceral disorders (e.g., patients with cardiac disorders exhibit active trigger points in the trapezius, levator scapulae, and rhomboideus muscles). In such cases the end-plate abnormalities do not have anything to do with formation of trigger points in the skeletal muscles. They are the result of the phenomenon of convergence of pain stimuli within the same segments of the spinal cord, which are responsible for the innervation of both the affected inner organ and the skeletal muscles. In 1955 Dr. Glezer and Dalicho formulated the theory that still stands clinically proven. They proposed and developed maps of reflex zone abnormalities of the skin, fascia and muscles, including trigger point development.The Energy Crisis TheoryThere is another theory, which links formation of trigger points with the shortage of ATP in the affected muscles as a result of insufficient arterial circulation.